|
KMID : 0377519810060040525
|
|
Chung-Ang Journal of Medicine
1981 Volume.6 No. 4 p.525 ~ p.532
|
|
|
Buffering Capacity of Sodium Bicarbonate during Induced Metabolic Acidosis in Dogs
|
|
Park Sun-Gyoo
Cho Hyung-Sang
|
|
|
Abstract
|
|
|
|
In the treatment of metabolic acidosis, sodium bicarbonate(NaHCO_3) is used frequently and the dose is usually calculated on the assumption that the administered bicarbonate distributes in a space ,equivalent to 30~50% of body weight. In a case of profound metabolic acidosis, the apparent space of distribution of bicarbonate can be markedly increased and influenced by the pre-existing plasma bicarbonate concentration. This theory was tested with a usual dose of bicarbonate (1.5 mmoles/kg of body weight) every 20 minutes in 10 dogs that had been made acidotic(ph 7.1 level) by intravenous administration of 0.6-N HCl. In addition to this, the pH and Pco_2 in cerebrospinal fluid(CSF) and arterial blood, serum potassium level, mean arterial pressure(MAP) and heart rate were measured throughout the experiment. The pH and Pco_2, of the CSF were normal or near it. MAP was significantly reduced but the heart rate did not show any significant change. There was an increase in serum potassium concentration during metabolic acidosis but it gradually decreased to normal levels as NaHCO_3 corrected this acidosis. The apparent space of distribution of bicarbonate was over 150% of the real body weight in severe metabolic acidosis(pH 7.116~7.138). These results indicate that the administration of NaHCO_3 corrected the acidosis and normalized the serum potassium level & MAP; but had little effect on CSF parameters & heart rate. Also the results suggest that in some conditions of profound metabolic acidosis commonly recomrnended amounts of bicarbonate may produce unexpectedly small increments in the plasma concentration.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|